Microfluidic chip for biomolecule crystallization

Details Microfluidic chip for biomolecule crystallization Microfluidic chip for biomolecule crystallization

G - Physics

01

N

G01N 1/00 (2006.01) B01L 3/00 (2006.01) C30B 7/00 (2006.01) G01N 1/18 (2006.01) B01L 3/06 (2006.01)

Patent

CA 2498332

A system for crystallizing a protein and other biomolecules, the general scheme of which is represented in Figure 1, comprises a flow channel (12) for conveying a solution containing the biomolecule to be crystallized and one or more substations (40, 50, 60, 70) related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through the flow channel (12), then performing dialysis on a micro- scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.

L'invention concerne un système de cristallisation d'une protéine et d'autres biomolécules, dont le schéma général est représenté dans la figure 1. Ledit système comprend un canal (12) d'écoulement servant au transport d'une solution contenant la biomolecule destinée à être cristallisée, et une ou plusieurs sous-stations (40, 50, 60, 70) associées au processus de cristallisation, formées le long du canal fluidique. Le système fonctionne par écoulement d'une solution de biomolécules dans le canal (12) d'écoulement, procédant ainsi à une dialyse à micro-échelle afin d'établir des conditions de cristallisation. Après la dialyse, la concentration de la solution de biomolécules change par retrait de l'eau ou du solvant de la solution de biomolécules afin de favoriser la formation de cristaux dans un segment du canal d'écoulement. Les cristaux formés peuvent être observés et récupérés dans le canal d'écoulement.

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