A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2334940
The present invention provides a novel method for treating neurodegenerative disease in mammals. This method involves the introduction of a therapeutic effective amount of a chaperone, a chaperone-like-compound or a compound which increases proteasome activity into the neurological system of the mammal. There is also a novel method for screening for compounds having chaperone-like activity or having activity to increase proteasome activity. The screening works in either cultured cells or animal models.
La présente invention porte sur un nouveau procédé de traitement des maladies neurodégénératives chez les mammifères. Ce procédé consiste à introduire une quantité thérapeutiquement efficace d'une molécule chaperonne, d'un composé de type molécule chaperonne ou d'un composé qui accroît l'activité des protéasomes dans le système neurologique du mammifère. L'invention porte en outre sur un nouveau procédé de criblage de composés ayant une activité de type chaperonnage ou une activité augmentant l'activité des protéasomes. Le criblage s'effectue soit dans les cellules mises en culture, soit dans les modèles animaux.
Cummings Christopher J.
Defranco Donald B.
Mancini Michael A.
Orr Harry T.
Stenoien David
Baylor College Of Medicine
Borden Ladner Gervais Llp
The University Of Minnesota
The University Of Pittsburgh Of The Commonwealth System Of Highe
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