Novel salts and polymorphs of desazadesferrithiocin...

Details Novel salts and polymorphs of desazadesferrithiocin... Novel salts and polymorphs of desazadesferrithiocin...

C - Chemistry, Metallurgy

07

D

C07D 277/22 (2006.01) A61K 31/426 (2006.01) A61P 9/02 (2006.01) A61P 9/10 (2006.01) A61P 25/08 (2006.01) C07D 277/20 (2006.01)

Patent

CA 2728636

Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

L'invention concerne de nouveaux sels et polymorphes d'analogues de polyéther de désazadesferrithiocine (DADFT-PE), et également des compositions pharmaceutiques les comportant et leur application comme agents de chélation de métaux pour le traitement d'une maladie. L'invention concerne également des procédés de chélation du fer et d'autres métaux chez un sujet humain ou animal en vue du traitement d'une surcharge de métaux et de la toxicité des métaux.

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