C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01)
Patent
CA 2496213
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
Aux fins de l'invention, on a déterminé que le clivage de la myostatine pro peptide dont la médiation est assurée par métalloprotéase induit l'activation d'une myostatine inactive latente sous forme active. L'invention concerne également des procédés relatifs à l'identification d'agents qui modulent l'activation de la myostatine dont la médiation est assurée par métalloprotéase, ainsi que des agents identifiés selon ces procédés. L'invention concerne par ailleurs des procédés relatifs à la modulation de la croissance musculaire dans un organisme, reposant sur l'augmentation ou la diminution du clivage d'une myostatine pro peptide dont la médiation est assurée par métalloprotéase.
Greenspan Daniel S.
Lee Se-Jin
Mcpherron Alexandra C.
Pappano William N.
Tomkinson Kathy
Osler Hoskin & Harcourt Llp
The Johns Hopkins University
Wisconsin Alumni Research Foundation
Wyeth
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