Synthesis of (s)-3-(thien-2-ylthio) butyric acid analogs

Details Synthesis of (s)-3-(thien-2-ylthio) butyric acid analogs Synthesis of (s)-3-(thien-2-ylthio) butyric acid analogs

C - Chemistry, Metallurgy

07

D

260/329.4

C07D 333/34 (2006.01)

Patent

CA 2040518

302/WHN28 18116 TITLE OF THE INVENTION SYNTHESIS OF (S)-3-(THIEN-2-YLTHIO)BUTYRIC ACID ANALOGS ABSTRACT OF THE DISCLOSURE (S)-3-(thien-2-ylthio)butyric acid analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno [2.3-b]thiopyran-2-sulfonamide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma. They are prepared by condensation of 2-mercaptothiophene and (R)-(+)- .beta.-methyl-.beta.-propiolactone or an analog thereof.

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