Use of long-chain n-alkyl derivatives of deoxynojirimycin...

Details Use of long-chain n-alkyl derivatives of deoxynojirimycin... Use of long-chain n-alkyl derivatives of deoxynojirimycin...

A - Human Necessities

61

K

A61K 38/47 (2006.01) A61K 31/44 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2378776

A novel combination drug therapy is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of both a N-alkyl derivative of deoxynojirimycin (DNJ) and a glucocerebrosidase enzyme to alleviate or inhibit the glycolipid storage disease. The alkyl group has from about two to about 20 carbon atoms and preferably is butyl, nonyl or decyl.

L'invention concerne une nouvelle combinaison de traitement médicamenteux, permettant de traiter un patient souffrant de la maladie de Gaucher ou d'autres maladies, notamment des maladies provoquées par le stockage de glycolipides. Le procédé consiste à administrer audit patient une quantité thérapeutiquement efficace d'un dérivé N-alkyle de déoxynojirimycine (DNJ) et d'un enzyme glucocérébrosidase afin de soulager ou d'inhiber les maladies provoquées par le stockage de glycolipides. Le groupe alkyle possède environ 2 à 20 atomes de carbone, et représente, de préférence, butyle, nonyle ou décyle.

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