Piperidine sulfonamide derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

IPC codes

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61P 25/20 (2006.01) C07D 211/96 (2006.01)

Type

Patent

Patent number

CA 2713713

Description

The present invention relates to piperidine sulphonamide derivatives of formula (I) wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds may be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.

La présente invention concerne des dérivés de pipéridine sulfonamide de formule (I) dans laquelle Ar1, Ar2, R1, R2, m et n sont définis dans la description et les revendications, ou leurs sels d'addition d'acide pharmaceutiquement appropriés. Les composés de formule I sont des antagonistes de récepteur d'orexine et les composés apparentés peuvent être utiles dans le traitement d'apnée du sommeil, narcolepsie, insomnie, parasomnie, syndrome du décalage horaire, troubles des rythmes circadiens ou troubles du sommeil associés à des maladies neurologiques.

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