Viral vectors and line for gene therapy

Details Viral vectors and line for gene therapy Viral vectors and line for gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2200696

Novel viral vectors in which the expression of viral genes is regulated in such a way that it is functional in a complementation cell and non-functional in a host cell, as well as viral particles and host cells containing said novel vectors, are disclosed. A complementation cell including a viral gene expression regulator, and a method for preparing infectious viral particles, are also disclosed. Finally, a pharmaceutical composition containing said vectors, and the therapeutical use thereof, are disclosed.

La présente invention concerne de nouveaux vecteurs viraux dans lesquels l'expression des gènes viraux est régulée de manière à être fonctionnelle dans une cellule de complémentation et non-fonctionnelle dans une cellule hôte ainsi que les particules virales et les cellules hôtes contenant ces nouveaux vecteurs. Elle a également pour objet une cellule de complémentation comprenant un régulateur de l'expression des gènes viraux ainsi qu'un procédé de préparation de particules virales infectieuses. Enfin, elle concerne une composition pharmaceutique les contenant et leur usage thérapeutique.

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