Substituted cinnolin-4-ylamines

Details Substituted cinnolin-4-ylamines Substituted cinnolin-4-ylamines

A - Human Necessities

61

K

A61K 31/4985 (2006.01)

Patent

CA 2557852

Substituted cinnolin-4-ylamines are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activityin vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des cinnolin-4-ylamines substituées de formule générale (I) dans laquelle les variables ont la signification indiquée dans la description. Lesdits composés sont des ligands pouvant servir à moduler l'activité d'un récepteur spécifique in vivo ou in vitro, et s'avèrent particulièrement utiles dans le traitement d'états associés à l'activation de récepteurs pathologiques chez l'être humain, les animaux domestiques et d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés pour le traitement desdits états, ainsi que de méthodes d'utilisation desdits ligands pour des études de localisation de récepteurs.

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