C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 35/76 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/50 (2006.01) C07K 1/00 (2006.01) C12N 9/78 (2006.01) C12N 15/00 (2006.01) C12N 15/869 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2376939
An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD has been inserted. A method of treatment of a patient suffering from cancer includes administering to the patient the anti-tumor pharmaceutical composition including an HSV vector having a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD inserted therein.
L'invention concerne un composé pharmaceutique anticancéreux comprenant un vecteur du virus de l'herpès simplex (HSV), dans lequel on a inséré une séquence d'acide nucléique codant pour un agent anticancéreux sélectionné à partir de l'interleukine 12, du facteur stimulant les colonies de granulocytes macrophages (GM-CSF), et de la cytoxine déaminase (CD). Ladite invention concerne également une méthode de traitement du cancer, par administration dudit composé pharmaceutique antitumoral, lequel comprend un vecteur du virus de l'herpès simplex (HSV) dans lequel on a inséré une séquence d'acide nucléique codant pour un agent anticancéreux sélectionné à partir de l'interleukine 12, du facteur stimulant les colonies de granulocytes macrophages (GM-CSF), et de la cytoxine déaminase (CD).
Gillespie George Yancey
Markert James Macdowell
Parker Jacqueline Ness
Whitley Richard J.
Ridout & Maybee Llp
Uab Research Foundation
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