Prophylactic and therapeutic agents and uses therefor

Details Prophylactic and therapeutic agents and uses therefor Prophylactic and therapeutic agents and uses therefor

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/53 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01)

Patent

CA 2620809

Treatment, detection and monitoring of disease of the nervous system, especially trauma or hypoxia, in particular in the central nervous system and the eye by up-regulation or increasing levels of Ndfipl (also known as Nedd4- WW Domain Binding Protein 5 or N4WBP5). Prophylaxis of such conditions in pre- term infants, coronary artery bypass graft, chemotherapy, tumour irradiation and other patients.

L~invention concerne le traitement, la détection et la surveillance d'une maladie du système nerveux, en particulier d'un trauma ou d~une hypoxie, en particulier du système nerveux central et de l'AEil, par augmentation de l~expression ou accroissement des niveaux de Ndfipl (aussi connu sous le nom de Protéine 5 de liaison du Domaine Nedd4-WW ou N4WBP5). Elle permet de prévenir ces conditions chez des prématurés, lors d'une greffe de déviation de l'artère coronaire, d'une chimiothérapie, d~une irradiation de tumeur et chez d~autres patients.

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