C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 50/28 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) C07C 39/19 (2006.01)
Patent
CA 2635280
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns- Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
L'invention concerne des procédés de traitement ou de suppression de maladies mitochondriales telles que l'ataxie de Friedreich (FRDA), la neuropathie optique héréditaire de Leber (LHON), le syndrome MELAS (myopathie mitochondriale, encéphalopathie, acidose lactique, accident vasculaire) ou le syndrome de Kearns et Sayre (KSS), ainsi que des composés utiles dans les procédés de l'invention. Elle concerne également des procédés et des composés utiles pour traiter d'autres pathologies. L'invention concerne en outre des biomarqueurs énergétiques utiles pour évaluer la condition métabolique d'un sujet et l'efficacité du traitement, des procédés permettant de moduler, normaliser ou activer des biomarqueurs énergétiques, ainsi que des composés utiles pour ces procédés.
Hecht Sidney M.
Jankowski Orion D.
Miller Guy M.
Mollard Paul
Wesson Kieron E.
Borden Ladner Gervais Llp
Edison Pharmaceuticals Inc.
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