Compositions methods and systems for pulmonary delivery of...

Details Compositions methods and systems for pulmonary delivery of... Compositions methods and systems for pulmonary delivery of...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2577451

Stable aqueous formulations which are free of products derived from human or animal origin and which maintain high biological activity and high chemical and physical stability of alpha-type interferon, and proteins in general, for an extended period of time. Methods of producing stable aerosol formulations of the same for delivery to the lungs are also provided, as well as systems and methods of delivering the formulations to the lungs for systemic absorption.

L'invention concerne des formulations aqueuses stables exemptes de produits d'origine humaine ou animale, et permettant de préserver une activité biologique ainsi qu'une stabilité physique et chimique élevées de l'interféron de type alpha, et des protéine en général, pendant une période prolongée. L'invention concerne également des procédés permettant de produire des formulations aérosols stables de ces compositions, destinées à l'administration pulmonaire, ainsi que des systèmes et des méthodes permettant l'administration pulmonaire desdites formulations en vue de leur absorption systémique.

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