Anti-il2 antibodies

Details Anti-il2 antibodies Anti-il2 antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2609234

The invention relates to a humanized monoclonal antibody or fragment thereof which specifically binds to human interleukin-2 (IL2), wherein said humanized monoclonal antibody neutralizes the activity of human IL2 by binding to said human IL2 prior to, during, and/or subsequent to the binding of said human IL2 to the human IL2-receptor, and wherein the light chain variable region of said humanized monoclonal antibody comprises in its second framework region the contiguous amino acid sequence KAPKA at amino acid positions 42-46.

L'invention concerne un anticorps monoclonal humanisé ou un de ses fragments, qui se fixe de manière spécifique à l'interleukine-2 (IL2) humaine. Cet anticorps monoclonal humanisé neutralise l'activité de l'IL2 humaine en se fixant à l'IL2 humaine avant, pendant et/ou après la fixation de l'IL2 humaine au récepteur de l'IL2 humaine. La région variable de la chaîne légère de l'anticorps monoclonal humanisé comprend, dans sa seconde région charpente, la séquence d'acides aminés contigus KAPKA aux positions 42-46 des acides aminés.

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