Mutant porcine reproductive and respiratory syndrome virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/40 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2586153

The present invention provides a genetically modified PRRS virus which has been modified such that the conserved cysteine in the E protein has been deleted or changed to a non-cysteine residue and polynucleotides that encode it. Vaccines comprising the genetically modified virus and polynucleotides are also provided.

Cette invention concerne un virus PRRS génétiquement modifié, qui a été modifié pour que la cystéine conservée dans la protéine E soit supprimée ou changée en résidu non-cystéine, et des polynucléotides codant pour un tel virus. L'invention concerne également des vaccins comprenant ce virus génétiquement modifié et les polynucléotides susmentionnés.

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