Indole and benzoxazine derivatives as modulators of...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/538 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2744138

The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2("mGluR2") and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

La présente invention porte sur de nouveaux dérivés d'indole et de benzoxazine qui sont de modulateurs allostériques positifs du sous-type 2 des récepteurs métabotropiques au glutamate (« mGluR2 ») et qui sont utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques associés à une dysfonction des récepteurs au glutamate et de maladies dans lesquelles le sous-type mGluR2 des récepteurs métabotropiques est impliqué. L'invention porte également sur des compositions pharmaceutiques comprenant de tels composés, sur des procédés pour préparer de tels composés et compositions et sur l'utilisation de tels composés pour la prévention ou le traitement de troubles et maladies neurologiques et psychiatriques dans lesquels mGluR2 est impliqué.

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