C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0735 (2010.01) A61K 35/12 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) C12Q 1/04 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2644856
A method of identifying an undifferentiated human embryonic stem cell in a sample which may contain such cells, the method comprising identifying the cell or cells within the sample that express podocalyxin-like protein (PODXL) on their surface. A method of isolating an undifferentiated human embryonic stem cell from a sample containing such cells, the method comprising isolating the cell or cells within the sample that express PODXL on their surface. Typically, the methods use an antibody which binds to PODXL. Undifferentiated human embryonic stem cells isolated by the method may be useful in cell therapy. Also, in particular, compositions of cells differentiated from a human embryonic stem cell but which composition has been depleted of undifferentiated human embryonic stem cells are provided which are useful in cell therapy.
L'invention concerne un procédé d'identification d'une cellule souche embryonnaire humaine non différenciée dans un échantillon qui contient ces cellules, ce procédé consistant à identifier la ou les cellules dans l'échantillon qui expriment la protéine de type podocalyxine (PODXL) sur leur surface. L'invention concerne également un procédé destiné à isoler une cellule souche embryonnaire humaine non différenciée d'un échantillon contenant ces cellules, le procédé consistant à isoler la ou les cellules dans l'échantillon qui exprime la PODXL sur leur surface. Généralement, les procédés utilisent un anticorps qui se lie à la PODXL. Les cellules souches embryonnaires humaines non différenciées isolées par le procédé peuvent être utilisées dans la thérapie cellulaire. L'invention concerne également des compositions de cellules différenciées d'une cellule souche embryonnaire humaine mais dont la composition a été appauvrie en cellules souches embryonnaires humaines non différenciées utiles dans la thérapie cellulaire.
Choo Andre
Ho Steve
Agency For Science Technology And Research
Gowling Lafleur Henderson Llp
LandOfFree
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