Crfg-1b, a target and marker for chronic renal failure

Details Crfg-1b, a target and marker for chronic renal failure Crfg-1b, a target and marker for chronic renal failure

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2228736

CRFG-1b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CRFG-1b polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal disease, renal ischemia, diabetic nephropathy, acute renal failure, Neurodegenerative disease, and Alzheimer's disease, among others, and diagnostic assays for such conditions.

Sont décrits des polynucléotides et des polypeptides CRFG-1b et des méthodes de production de ces polypeptides par des techniques d'ADN recombinant. Sont également décrites des méthodes d'utilisation des polynucléotides et des polypeptides CRFG-1b dans la conception de protocoles de traitement, entre autres, de la néphropathie chronique, de l'ischémie rénale, de la néphropathie diabétique, de l'insuffisance rénale aiguë, des maladies neurodégénératives et de la maladie d'Alzheimer, ainsi que d'épreuves diagnostiques de ces états pathologiques.

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