C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/18 (2006.01) A61K 31/197 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/423 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/4465 (2006.01) A61K 31/4545 (2006.01) A61K 31/535 (2006.01) A61
Patent
CA 2285405
An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
La présente invention concerne un composé d'acide hydroxamique sulfonamide à cycle amidoaromatique qui inhibe notamment une activité de métalloprotéase matricielle (MMP). La présente invention concerne également un procédé de traitement qui consiste à administrer le composé d'acide hydroxamique sulfonamide à cycle amidoaromatique en question, à raison d'une quantité efficace destinée à inhiber l'activité d'un enzyme MMP, à un hôte présentant un état associé à l'activité pathologique de métalloprotéase matricielle.
Abbas S. Zaheer
Decrescenzo Gary A.
Getman Daniel P.
Heintz Robert M.
Howard Susan C.
Monsanto Company
Osler Hoskin & Harcourt Llp
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