Triazole compounds useful as protein kinase inhibitors

Details Triazole compounds useful as protein kinase inhibitors Triazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) A61P 25/18 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/16 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2422299

This invention describes novel triazole compounds of formula (IX): wherein Z1~ is nitrogen or CR9~ and Z2~ is nitrogen or CH, provided that at least one of Z1~ and Z2~ is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from -R1~; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx~ and Ry~ are independently selected from T-R3~, or Rx~ and Ry~ are taken together with their intervening atoms to form a fused ring; R1~, R3~, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.

L'invention porte sur de nouveaux compos~s de triazole de formule (IX): dans laquelle: Z?1´ est azote ou CR?9´ et Z?2´ est azote ou CH, sous r~serve que l'un de Z?1´ et Z?2´ soit azote; G est cycle C or cycle D; cycle C est choisi parmi ph~nyle, pyridinyle, pyrimidinyle, pyridazinyle, pyrazinyle, ou cycle1,2,4-triazinyle, ledit cycle C ayant un ou deux substituants ortho choisis ind~pendamment parmi -R?1´; cycle D est un cycle monocyclique ~ 5-7 ~l~ments ou un cycle bicyclique ~ 8-10 ~l~ments 8-10, choisi parmi aryle, h~t~roaryle, h~t~rocyclyle ou carbocyclyle; R?x´ et R?y´ sont choisis ind~pendamment parmi T-R?3´, ou R?x´ et R?y´ pris ensemble avec leurs atomes intervenant forment un cycle fusionn~; R?1´, R?3´, et T sont d~crits dans la sp~cification. Lesdits compos~s sont des inhibiteurs de la prot~ine kinase et sp~cialement des inhibiteurs de la GSK-3 et de l'Aurora, pouvant traiter des maladies telles que la diab­te, le cancer ou la maladie d'Alzheimer.

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