Substituted imidazoles as dual histamine h1 and h3 agonists...

Details Substituted imidazoles as dual histamine h1 and h3 agonists... Substituted imidazoles as dual histamine h1 and h3 agonists...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2421826

Novel substituted imidazole compounds of formula (I): (see formula I) have dual histamine-H1 and H3 receptor antagonist activity; methods for preparing such compounds are provided as well pharmaceutical compositions comprising such imidazoles and methods of using them to treat allergy, inflammatory and CNS-related diseases and others.

La présente invention concerne de nouveaux composés imidazole substitués qui possèdent une double activité antagoniste du récepteur d'histamine H1 et H2, ainsi que des techniques de préparation de ces composés. Dans un autre mode de réalisation, cette l'invention concerne des compositions pharmaceutiques comprenant ces imidazoles, ainsi que des techniques d'utilisation de ces compositions pour traiter des allergies, des maladies inflammatoires et des maladies liées au système nerveux central.

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