C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/18 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2243191
A method of diagnosis comprises determining genotype of a TGF-.beta.1 promoter - specific polymorphisms that have been identified are at positions-800bp and - 509bp. The genotype determined is then used to assess predisposition or susceptibility to a number of diseases: osteoporosis, atherosclerosis, cancer and immune disorders.
L'invention concerne un procédé de diagnostic consistant à déterminer le génotype d'un promoteur du TGF-.beta.1, à savoir des polymorphismes spécifiques ayant été identifiés comme se trouvant aux positions-800bp et -509bp. Le génotype déterminé sert ensuite à évaluer la prédisposition à un certain nombre de maladies comme l'ostéoporose, l'athérosclérose, le cancer et les troubles immunitaires.
Grainger David John
Heathcote Kirsten
Spector Timothy David
Goudreau Gage Dubuc
Grainger David John
Sequenom-Gemini Limited
Spector Timothy David
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