Rapamycin derivatives useful as immunosuppressants

Details Rapamycin derivatives useful as immunosuppressants Rapamycin derivatives useful as immunosuppressants

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/436 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2174731

Novel demethoxy derivatives of rapamycin of formula (I) are found to have pharmaceutical utility, particularly as an immunosuppressants. In formula (I) R2 = formula (II) or formula (III), X, Y, R1, R3, R3, R4, R5 are as defined in the application.

L'invention concerne des nouveaux dérivés déméthoxy de la rapamycine de formule (I) utiles dans le domaine pharmaceutique, en particulier en tant qu'immunosuppresseurs. Dans cette formule (I), R¿2? est représenté par la formule (II) ou (III). Dans les formules (I), (II) et (III), X, Y, R¿1?, R¿3?, R¿4?, R¿5? sont tels que définis dans la demande.

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