C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/70 (2006.01) C07D 311/58 (2006.01)
Patent
CA 2089013
ABSTRACT A process for the preparation of aminochroman of the general formula Image I where R is a lower alkyl group having 1 to 4 C atoms, is described. In this process, nitrochromanone of the general formula Image II is reduced using zirconium oxide/isopropanol to produce a mixture of a corresponding aminochromene Image III and a corresponding nitrochromene Image IV This mixture is then hydrogenated with hydrogen in the presence of a hydrogenation catalyst to produce the final product, of the general formula I. Aminochroman is an important intermediate in the preparation of hypolipidaemic pharmaceuticals.
G. Ronald Bell & Associates
Lonza Ltd.
Sankyo Company Limited
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