Enhancer sequence of the 5-aminolevulinic acid synthase gene

Details Enhancer sequence of the 5-aminolevulinic acid synthase gene Enhancer sequence of the 5-aminolevulinic acid synthase gene

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12N 15/52 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2478939

Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis are described.

Séquences d'acide nucléique intervenant dans l'expression du gène de 5-aminolévulinate synthase (ALAS1) induite par un composé chimique. Ces séquences comprennent au moins un site de liaison à DR-4. L'invention concerne aussi des procédés in vitro pour tester des composés chimiques modulant la synthèse de l'hème et/ou des cytochromes P 450.

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