Methods of modulating inflammation and compositions therefore

Details Methods of modulating inflammation and compositions therefore Methods of modulating inflammation and compositions therefore

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/20 (2006.01) G01N 33/53 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2688256

The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the invention include modulating an IL-13/sIL-13R.alpha.2 complex and methods of modulating expression of various nucleotide sequences of interest including Pira1, Vannin1 and ApoA1. In an aspect, the methods of the invention allow detection of an altered IL-13/sIL-13R.alpha.2 complex level in a subject. Further aspects of the invention allow for identification of subjects suitable for inclusion in a sIL-13R.alpha.2 related study or inflammatory related disorder study.

L'invention concerne des compositions et des procédés utiles pour la détection ou le traitement de l'asthme ou d'autres maladies allergiques ou inflammatoires. Dans un aspect, les procédés de l'invention comprennent la modulation d'un complexe d'IL-13/sIL-13R.alpha.2 et des procédés de modulation de l'expression de diverses séquences nucléotidiques intéressantes, y compris Pira1, Vannin1 et ApoA1. Dans un aspect, les procédés de l'invention permettent de détecter un taux modifié du complexe d'IL-13/sIL-13R.alpha.2 chez un sujet. D'autres aspects de l'invention permettent d'identifier des sujets pouvant être inclus dans une étude liée à sIL-13R.alpha.2 ou une étude des troubles inflammatoires associés.

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