C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/28 (2006.01) A61K 38/19 (2006.01) C07K 14/525 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2091313
RAN 4105/147 Abstract The present invention is directed to a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof having selective binding affinity for the human p55-Tumor-Necrosis-Factor-Receptor characterized in that the amino acid sequence of human Tumor Necrosis Factor is changed at least at position 86 showing a threonine instead of a serine residue, a DNA sequence coding for such a mutein, a vector comprising such a DNA sequence, a host cell transformed by such a vector, a process for the production of such muteins by such host cells, pharmaceutical compositions containing such a mutein and the use of such a mutein for the treatment of illnesses.
Lesslauer Werner
Lotscher Hansruedi
Stuber Dietrich
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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