C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 38/19 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2206496
An object of the present invention is to provide a physiologically active substance having activity in acting on the megakaryocyte-platelet system, in promoting the differentiation and maturation of megakaryocytes, and in promoting the formation of platelets. The present invention relates to a thrombocytopoiesis stimulating factor, characterized in having the following amino acid sequence in its molecule, and to a medicinal composition for treating thrombocytopenia, characterized in containing said thrombocytopoiesis stimulating factor as an active component: xaa Gly Asn Asn Asp Glu Ser Asn Ile Ser Phe Lys Glu Lys Asp Ile (where Xaa indicates that the amino acid is unspecified). The aforementioned physiologically active substance is useful as an active component or the like in therapeutics and preventives for thrombocytopenia and thrombocytopenic purpura associated with chemotherapy and marrow grafts, and for various other diseases which are prone to bleeding attributed to thrombocytopenia.
Substance physiologiquement active agissant sur le système mégakaryocytes-plaquettes, en favorisant la différenciation et la maturation des mégakaryocytes, ainsi que la formation des plaquettes. L'invention concerne un facteur de simulation de la thrombocytopoïèse, caractérisé par la présence dans sa molécule de la séquence d'acides aminés ci-dessous, et par une composition médicinale pour le traitement de la thrombocytopénie, renfermant ce facteur comme principe actif : xaa Gly Asn Asn Asp Glu Ser Asn Ile Ser Phe Lys Glu Lys Asp Ile (Xaa signifie que l'acide aminé n'est pas spécifié). La substance physiologiquement active mentionnée précédemment est utile comme principe actif ou agent de même type dans des produits de traitement et de prévention pour la thrombocytopénie et le purpura thrombocytopénique associés à la chimiothérapie et aux greffes de moelle osseuse, ainsi que pour diverses autres maladies présentant des saignements attribuables à la thrombocytopénie.
Higuchi Masato
Kawakita Makoto
Matsuzaki Hiromitsu
Shibuya Kazushi
Takatsuki Kiyoshi
Chugai Seiyaku Kabushiki Kaisha
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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