C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 1/20 (2006.01) C12N 9/10 (2006.01) C12N 9/90 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2395378
The present invention disclosed isolated nucleic acid molecules (polynucleotides) which encode NHL, a putative DNA helicase. The present invention in turn relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding NHL, substantially purified forms of associated NHL, associated mutant proteins, and methods associated with identifying compounds which modulate NHL, which will be useful in the treatment of various neoplastic disorders. Both a genomic clone containing regulatory and intron sequences, as well as the exon structure and open reading frame of human NHL are disclosed.
La présente invention concerne des molécules d'acide nucléique isolé (oligonucléotides) qui codent la NHL que l'on suppose être une hélicase d'ADN. L'invention concerne plus particulièrement des vecteurs de recombinaison et des hôtes de recombinaison contenant un fragment d'ADN codant la NHL, des formes sensiblement purifiées de la NHL associée, des protéines mutantes associées, et des procédés associés visant à identifier des composés qui modulent la NHL et qui devraient convenir au traitement de divers troubles néoplasiques. L'invention concerne également, d'une part un clone génomique contenant des séquences régulatrices et d'intron, et d'autre part la structure d'exon et un cadre de lecture ouvert de la NHL humaine.
Bai Chang
Liu Xiaomei
Metzker Michael L.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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