Tweak as a therapeutic target for treating central nervous...

Details Tweak as a therapeutic target for treating central nervous... Tweak as a therapeutic target for treating central nervous...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2587018

The present invention is directed to compositions and methods for treating cerebral edema and cell death in neurological conditions characterized by disruption of the architecture of the neurovascular unit with increase in the permeability of the NVU, particularly for treating stroke. One aspect of the present invention relates to a composition comprising an agent that interferes with a TWEAK-mediated signaling pathway. Another aspect of the present invention relates to a method of using a composition which comprises an agent that inhibits Fn14 activity or Fn14 expression for the prevention and/or treatment of cerebral edema and cell death occurring in certain neurological conditions such as cerebral ischemia.

La présente invention concerne des compositions et procédés de traitement d'un oedème cérébral et d'une mort cellulaire dans des conditions neurologiques caractérisées par l'interruption de l'architecture de l'unité neurovasculaire avec augmentation dans la perméabilité de l'unité neurovasculaire NVU, notamment pour traiter l'accident vasculaire cérébral. Un aspect de la présente invention concerne une composition contenant un agent qui interfère avec un passage de signalisation à médiation par TWEAK faible inducteur d'apoptose de type facteur de nécrose des tumeurs-. Un autre aspect de la présente invention concerne un procédé d'utilisation d'une composition contenant agent qui inhibe l'activité Fn14 ou l'expression Fn14 pour prévenir et/ou traiter un oedème cérébral et la mort cellulaire survenant dans certains états neurologiques tels que l'ischémie cérébrale.

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