Pyridone derivatives having a binding activity to the...

Details Pyridone derivatives having a binding activity to the... Pyridone derivatives having a binding activity to the...

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/465 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/473 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07D 213/69 (2006.01) C07D 213/70 (2006.01) C07D 213/75 (2006.01) C07D 215/227 (2006.01) C0

Patent

CA 2433158

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): (see formula I) wherein R1 is a group represented by the formula: -Y1-Y2-Y3-R a wherein Y1 is single bond or the like; Y2 is -C(=O)-NH- or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.

Composé ayant une affinité pour le récepteur cannabinoïde de type 2, qui est représenté par la formule (I) dans laquelle R<1> représente un groupe représenté par la formule -Y<1>-Y<2>-Y<3>-Ra (dans laquelle Y<1> représente une liaison simple, etc. ; Y<2> représente C(=O)-NH-, etc. ; et Y<3> représente aryle éventuellement substitué, etc.), R<2> représente hydrogène, etc., R<3> représente alkyle, etc., R<4> représente alkyle, etc., et R<5> représente alkyle éventuellement substitué, etc., à condition que R<3> et R<4> puissent représenter, en combinaison, un noyau en coopération avec les atomes adjacents, etc.

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