Selective 6-acylation of sucrose mediated by cyclic adducts...

C - Chemistry – Metallurgy – 07 – H

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260/233.1

C07H 13/02 (2006.01) C07F 7/22 (2006.01) C07H 13/04 (2006.01) C07H 13/06 (2006.01) C07H 13/08 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2038740

There is disclosed a process which comprises the steps of: (a) reacting a di(hydrocarbyl)tin oxide such as a dialkyltin oxide with a dihydric alcohol, alkanolamine, or an enolizable .alpha.-hydroxy ketone in an inert organic reaction vehicle, with removal of water, at a temperature and for a period of time sufficient to produce a cyclic adduct of said dialkyltin oxide and said dihydric alcohol, alkanolamine, or enolizable .alpha.-hydroxy ketone; (b) reacting said cyclic adduct product of Step (a) with sucrose in an inert organic reaction vehicle such as a dipolar aprotic liquid, at a temperature and for a period of time sufficient to produce a 6-O-[dihydrocarbyl- (hydroxy- or amino- or oxohydrocarbyl)stannoxyl]sucrose; and (c) reacting the product of Step (b) with an acylating agent to produce a sucrose-6-ester.

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