Therapeutic composition, novel compounds useful therein and...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01)

Patent

CA 1050429

THERAPEUTIC COMPOSITION, NOVEL COMPOUNDS USEFUL THEREIN AND METHOD OF USING THE SAME ABSTRACT OF THE DISCLOSURE The invention provides a novel therapeutic composition comprising a pharmaceutically acceptable carrier containing a therapeutically effective amount of an ethereal monosubstitution of a monosaccharide derivative having the general formula S-O-Y, wherein S is the residue of the monosaccharide derivative se- lected from the group consisting of pentoses, hexoses and heptoses as single or polysubstituted acetals or esters and Y is selected from the group consisting of cyclic monovalent nitrogen-containing organic radicals and residua and monovalent organic radicals and residua having the general formula Image , wherein Rl is a divalent organic radical having a linear carbon chain length of about 1-7 carbon atoms and R2 and R3 are selected from the group consisting of -H, -OH, -SH, halogen and monovalent organic radicals and residua having a linear carbon chain length of about 1-7 carbon atoms. The invention also provides certain novel ethereal monosubstitutions of monosaccharide derivatives, of which 3-O-3'-(N',N'-dimethyl- amino-n-propyl)-1,2-O-isopropylidene-D-glucofuranose is an example. The novel compositions show striking antiviral activity or other therapeutically valuable properties.

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