Sulfonylated heterocycles useful for modulation of the...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/404 (2006.01) A61K 31/4709 (2006.01) A61P 3/00 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2679380

Compounds of the following structure are provided, wherein R1-R4 and R6-R9 are defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms.

L'invention concerne des composés de la structure suivante, où R1 à R4 et R6 à R9 sont définis ci-dessous, de même que des procédés de préparation et d'utilisation de ces composés pour la contraception, le traitement ou la prévention de fibromyomes, le léiomyome utérin, l'endométriose, l'hémorragie dysfonctionnelle, le syndrome des ovaires polykystiques ainsi que des carcinomes dépendant des hormones, la fourniture d'une thérapie de substitution hormonale, la stimulation de ration alimentaire, la synchronisation de l'AEstrus et le traitement des symptômes relatif au cycle menstruel.

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