Novel tetrahydropyridines, method for the preparation...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 409/14 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2395969

The invention concerns compounds of: formula (I) wherein: R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n and n' each independently represent 0 or 1;* represents the binding positions; A represents N or CH; X represents a sulphur or oxygen atom; R4 and R5 independently represent a hydrogen atom or a(C1-C6) alkyl group, as well as their salts or solvates. The invention also concerns a method for preparing said compounds and pharmaceutical compositions containing them.

La présente invention concerne des composés de formule (I) dans laquelle R1 représente un atome d'hydrogène ou d'halogène ou un groupe CF3; R2 et R3 représentent indépendamment un atome d'hydrogène ou un groupe méthyle; n et n' représentent chacun indépendamment 0 ou 1; represente les positions de rattachement; A représente N ou CH; X représente un atome de souffre ou d'oxygène; R4 et R5 représentent indépendamment un atome d'hydrogène ou un groupe (C1-C6) alkyle; ainsi que leurs sels ou solvates, un procédé pour leur préparation et les compositions pharmaceutiques les contenant.

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