Erbb4 antagonists

Details Erbb4 antagonists Erbb4 antagonists

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2420062

The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

L'invention concerne des procédés et des moyens permettant de réguler une prolifération et/ou une migration excessive de cellules musculaires lisses, et notamment de traiter la sténose, par l'utilisation d'agonistes d'un récepteur ErbB4 natif. L'invention concerne également un procédé d'identification d'agonistes et d'antagonistes de ErbB4 capables d'inhiber ou de favoriser la prolifération ou la migration de cellules musculaires souples.

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