Mixtures of triblock polyesterpolyethylene glycol copolymers

Details Mixtures of triblock polyesterpolyethylene glycol copolymers Mixtures of triblock polyesterpolyethylene glycol copolymers

C - Chemistry, Metallurgy

08

L

C08L 67/04 (2006.01) A61K 9/00 (2006.01) A61K 38/00 (2006.01) A61K 47/34 (2006.01) C08L 53/00 (2006.01) C08L 67/00 (2006.01)

Patent

CA 2407298

A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.

Système de gélification thermique inverse biodégradable soluble dans l'eau comprenant un mélange d'au moins deux types de constituants copolymères tribloc. Ces constituants copolymères tribloc comprennent un bloc de A-polymère de polyester biodégradable hydrophobe et un bloc de B-polymère de polyéthylèneglycol hydrophile. Les vitesses de libération du médicament et d'érosion de la matrice de gel de ce système de gélification thermique inverse biodégradable peuvent être modulées par différents paramètres, tels que les contenus des constituants hydrophobes/hydrophiles, les concentrations des blocs polymères, les poids moléculaires et les températures de gélification, ainsi que les rapports de poids des constituants copolymères tribloc du mélange.

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