Prognosis in cancer patients vaccinated with a cancer...

G - Physics – 01 – N

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G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2538300

The correlation of clinical benefits and immune responses to peptides in cancer patients who were vaccinated with CTL-directed peptides is shown. The invention relates to a process for determining prognosis in a cancer patient vaccinated with a cancer antigen peptide-associated agent, which comprises measuring a level of an antibody specific to the cancer antigen peptide, and assessing whether the level is significantly increased as compared to the level at pre-vaccination.

La corrélation entre des bénéfices cliniques et des réponses immunitaires à des peptides chez des patients atteints d'un cancer, qui ont été vaccinés au moyen de peptides présentés aux lymphocytes T cytotoxiques, est montrée. Cette invention concerne un procédé pour établir un pronostic chez un patient atteint d'un cancer et vacciné au moyen d'un agent associé à un peptide antigénique tumoral, lequel procédé consiste à mesurer un niveau d'un anticorps spécifique au peptide antigénique tumoral et à évaluer si ce niveau s'est considérablement accru par rapport au niveau observé avant la vaccination.

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