Hedgehog pathway modulators

Details Hedgehog pathway modulators Hedgehog pathway modulators

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 217/08 (2006.01) C07D 401/02 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2733533

The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of- function, smoothened gain-of- function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Linvention concerne un procédé, des composés et des compositions servant à moduler lactivité de la voie de signalisation Hedgehog. En particulier, linvention concerne un procédé permettant dinhiber les états de croissance aberrants résultant de phénotypes tels que la perte de fonction Ptc, le gain de fonction Hedgehog, le gain de fonction Smoothened ou le gain de fonction Gli, comprenant le contact dune cellule avec une quantité suffisante dun composé de formule (I).

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