Treatment of sepsis by low dose administration of tissue...

Details Treatment of sepsis by low dose administration of tissue... Treatment of sepsis by low dose administration of tissue...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/57 (2006.01)

Patent

CA 2463738

Methods for prophylactically or therapeutically treating sepsis or septic shock involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from sepsis or other inflammatory conditions. The methods involve the use of continuous intravenous infusion of TFPI or a TFPI analog at low doses to avoid adverse side effects.

L'invention concerne des procédés de prévention ou de traitement d'une maladie infectieuse ou d'un choc septique comportant l'administration d'un inhibiteur de voie d'accès de thromboplastine tissulaire (TFPI) ou d'un analogue TFPI à des patients souffrant d'une maladie infectieuse ou d'autres états inflammatoires. Ces procédés recourent à l'utilisation d'une injection intraveineuse d'un TFPI ou d'un analogue TFPI à faibles doses pour éviter les effets secondaires fâcheux.

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