Method of using m1-selective antimuscarinic...

Details Method of using m1-selective antimuscarinic... Method of using m1-selective antimuscarinic...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2087510

163FPG/ - i - 18651 TITLE OF THE INVENTION METHOD OF USING M1-SELECTIVE ANTIMUSCARINIC PYRIDOBENZODIAZEPINONES IN AXIAL MYOPIA THERAPY ABSTRACT OF THE INVENTION Pyridobenzodiazepinones of the formula: Image wherein R is piperidine substituted by C1-C5 alkyl, are ocularyl administered to animals to prevent abnormal increases in eye axial length and thereby 163FPG/ - ii - 18651 arrest the progression of axial myopia. The compounds are pharmacologically characterized in that they selectively antagonize the binding of acetylcholine to M1-type muscarine receptors.

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