Use of compounds for the prevention of drug-induced cell...

Details Use of compounds for the prevention of drug-induced cell... Use of compounds for the prevention of drug-induced cell...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 31/137 (2006.01) A61K 31/132 (2006.01) A61K 31/14 (2006.01) A61K 31/15 (2006.01) A61K 31/155 (2006.01) A61K 31/34 (2006.01) A61K 31/351 (2006.01) A61K 31/4035 (2006.01) A61K 31/435 (2006.01) A61K 31/439 (2006.01) A61K 31/444 (2006.01) A61K 31/495 (2006.01) A61P 43/00 (2006.01)

Type

Patent

Patent number

CA 2581489

Description

The present invention relates to the use of compounds for the manufacture of a me~dicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephewrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment, the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of docking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.

La présente invention concerne l'utilisation de composés destinés à la fabrication d'un médicament pour la prévention et/ou le traitement d'une toxicité cellulaire induite, telle qu'une néphrotoxicité et une ototoxicité, notamment lorsque cette toxicité cellulaire est induite par un traitement médical. Dans un mode de réalisation préféré, ces composés renferment au moins deux atomes d'azote, de préférence au moins deux groupes amino. Les composés de l'invention sont capables de couper la liaison de composés toxiques pour les cellules au récepteur de la mégaline, ce qui inhibe le captage de ces composés toxiques dans les cellules. L'invention concerne également de nouveaux composés utilisés dans ce traitement ainsi qu'un procédé destiné à réduire la toxicité cellulaire de composés toxiques pour les cellules.

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