Lactam tachykinin receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/26 (2006.01) A61K 31/4015 (2006.01) A61P 13/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2570813

The present invention is directed to certain lactam compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

La présente invention concerne certains composés lactamiques convenant en tant qu'antagonistes du récepteur de la neurokinine-1 (NK-1) et en tant qu'inhibiteurs de la tachykinine, en particulier la substance P. L'invention concerne également des préparations pharmaceutiques contenant ces composés comme principe actif et leur formulation pour le traitement de certains troubles, dont les vomissements, l'incontinence urinaire, la dépression et l'angoisse.

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