Proteases comprising one or more combinable mutations

Details Proteases comprising one or more combinable mutations Proteases comprising one or more combinable mutations

C - Chemistry, Metallurgy

12

N

C12N 9/54 (2006.01) C11D 3/386 (2006.01) C11D 7/42 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2743302

The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.

La présente invention concerne des variants de protéase artificiels. En particulier, les variants de protéase comprennent des mutations combinables à des positions de surface sélectionnées qui affectent la charge et/ou lhydrophobicité de lenzyme pour renforcer au moins une propriété souhaitée de lenzyme variante résultante dans une application choisie. La présente invention concerne en outre des compositions comprenant les variants de protéase, et des procédés dutilisation de celles-ci.

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