A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/17 (2006.01) A61K 31/426 (2006.01) A61K 31/54 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2657480
Antagonists of S1P3 (Edg-3) receptors are provided for attenuation of Smad signaling in a method of down-regulation of receptor signaling and downstream decreased production of connective tissue growth factor in ocular disorders involving CTGF accumulation. Ocular disorders involving inappropriate CTGF accumulation include ocular hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and ocular wound healing, for example. Such disorders are treated by administering antagonists of the present invention.
L'invention concerne des antagonistes des récepteurs S1P3 (Edg-3) destinés à atténuer la signalisation de Smad dans un procédé de régulation à la baisse de la signalisation de récepteur et de production réduite en aval du facteur de croissance du tissu conjonctif dans des troubles oculaires impliquant une accumulation du CTGF. Les troubles oculaires impliquant une accumulation impropre du CTGF englobent l'hypertension oculaire, le glaucome, la rétinopathie glaucomateuse, la neuropathie optique, la dégénérescence maculaire, la rétinopathie diabétique, la néovascularisation choroïdale, la vitréorétinopathie proliférative et la cicatrisation oculaire, par exemple. Ces troubles sont traités par administration d'antagonistes selon l'invention.
Fleenor Debra L.
Pang Iok-Hou
Shepard Allan R.
Alcon Research Ltd.
Kirby Eades Gale Baker
LandOfFree
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