Anti-gm-csf antibodies and uses therefor

Details Anti-gm-csf antibodies and uses therefor Anti-gm-csf antibodies and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07K 16/24 (2006.01) C07K 16/46 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2608498

The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

L'invention concerne des zones de liaison à des antigènes recombinants, des anticorps et des fragments fonctionnels de ceux-ci spécifiques à GM-CSF jouant un rôle déterminant dans des troubles et dans des états pathologiques variés. Les anticorps de l'invention peuvent être utilisés pour traiter, par exemple, des maladies inflammatoires, notamment de l'arthrite rhumatoïde. Les anticorps de l'invention peuvent également être utilisés dans le domaine des diagnostics, ainsi que pour des recherches concernant le rôle de GM-CSF dans l'évolution de troubles variés. L'invention concerne encore des séquences d'acide nucléique codant les anticorps susmentionnés, des vecteurs contenant ceux-ci, des compositions pharmaceutiques et des trousses associées accompagnées de leur mode d'emploi.

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