Tetrahydrocyclopenta[c]acridine derivatives as kinase...

Details Tetrahydrocyclopenta[c]acridine derivatives as kinase... Tetrahydrocyclopenta[c]acridine derivatives as kinase...

A - Human Necessities

61

K

A61K 31/473 (2006.01) A61P 3/10 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2711931

The invention relates to kinase inhibitors of the formula (I) in which - R1 to R4 = H; ether or polyether, amino; NO2; NH- carbamate; NH-CO-R, with R such as defined above; N3 and derivatives thereof of the 1, 2, 3-triazole type; - R5 = -OH; halogen; -OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH-CO-R, with R such as defined above; N3 and derivatives thereof of the 1, 2, 3-triazole type; N(R9, R10); - R5' = H or a C1-C12 alkyl, - R6 = H; R; (R or R')3-Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; - R7 and R8 = H, C1-C12 alkyl; - R9 and R10 = H, R (or R') such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.

Inhibiteurs de kinases de formule (I) R1 à R4 = H; éther ou polyéther, amino; NO2; NH-carbamate; NH-CO-R, avec R tel que défini ci-dessus; N3 et ses dérivés de type 1, 2, 3-triazole;- R5 = - OH; halogène; -OR avec R tel que défini ci-dessus; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH-CO-R, avec R tel que défini ci-dessus; N3 et ses dérivés de type 1, 2, 3-triazole; N(R9, R10);- R5' = H ou un alkyle C1-C12,- R5 = H; R; (R ou R')3- Si, R étant tel que défini ci-dessus; aryle le cas échéant substitué, hétéroaryle; halogène (iode); alcynyle; - R7 et R3 = H, alkyle C1- C12; - R9 et R10 = H, R (ou R') tel que défini ci-dessus. Application comme inhibiteurs de kinases notamment pour le traitement de cancers.

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