C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/26 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) C07D 239/30 (2006.01) C07D 239/47 (2006.01) C07D 295/26 (2006.01) C07D 309/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2529468
The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one or more ring heteroatoms wherein each said heteroatom is nitrogen; R2 represents a group selected from C1-6 alkyl or aryl, which said group is substituted by one or more fluorine groups; n is 1, 2 or 3; and R1 represents an optionally substituted group selected from C1-6 alkyl, C5-7 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, C1-6alkyl-heteroaryl, C1-6 alkyl-cycloalkyl or C1-6alkyl- heterocycloalkyl. Processes for their preparation; pharmaceutical compositions containing them; and their use in the treatment of a desease condition mediated by one or more metalloproteinase enzymes.
L'invention concerne des composés représentés par la formule (I) ou un sel, promédicament ou solvate pharmaceutiquement acceptable de ces composés : B est un cycle aryle monocyclique portant six atomes de cycle, ou un cycle hétéroaryle monocyclique portant jusqu'à six atomes de cycle, et contenant un ou plusieurs hétéroatomes de cycle, les hétéroatomes étant chacun azote ; R2 est un groupe choisi parmi C¿1-6?-alkyle ou aryle, substitué par un ou plusieurs groupes fluor ; n est 1, 2 ou 3 ; et, R¿1? est un groupe éventuellement substitué choisi parmi C¿1-6?-alkyle, C¿5-7?-cycloalkyle, hétérocycloalkyle, aryle, hétéroaryle, C¿1-6?-alkylaryle, C¿1-6?-alkylhétéroaryle, C¿1-6?-alkylcycloalkyle ou C¿1-6?-alkylhétérocycloalkyle. L'invention concerne également des procédés de fabrication de ces composés, des compositions pharmaceutiques les contenant, ainsi que leur utilisation dans le traitement d'une maladie à médiation par une ou plusieurs enzymes de métalloprotéinase.
Finlay Maurice Raymond Verschoyle
Waterson David
Astrazeneca Ab
Fetherstonhaugh & Co.
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