Influenza vaccines including combinations of particulate...

Details Influenza vaccines including combinations of particulate... Influenza vaccines including combinations of particulate...

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2628328

Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgGl). This response can be shifted towards a THl response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.

Il a été démontré que les vaccins Influenza contenant des adjuvants particulaires insolubles provoquent une réponse IgG qui est principalement une réponse TH2 (IgG1). Cette réponse peut être modifiée en réponse TH1 (IgG2a) par ajout d'immunopotentiateurs dans les compositions. L'invention propose ainsi une composition immunogène qui comprend : (i) un antigène de virus influenza ; (ii) un adjuvant particulaire insoluble ; et (iii) un immunopotentiateur.

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