Heterocyclic amido prostaglandin analogs

Details Heterocyclic amido prostaglandin analogs Heterocyclic amido prostaglandin analogs

C - Chemistry, Metallurgy

07

D

C07D 493/08 (2006.01) A61K 31/41 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2059906

HA558 ABSTRACT HETEROCYCLIC AMIDO PROSTAGLANDIN ANALOGS Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula Image wherein: m is 1, 2, or 3; n is 0, 1, 2 or 3; R is CO2R', CH2OH, CONHSO2R3, CONHR4, or -CH2-5-tetrazolyl; R' is hydrogen, alkyl, or alkali metal; X is O or NH; Y is -O-, a single bond or vinylene, except that Y cannot be -O- when n is O and if Y is vinylene, then n=o; Z is -CH=CH-, -(CH2)2-, or Image ; and the remaining symbols are as defined in the specification.

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